Planning
Wednesday, September 3, 2014
| Time |
Event |
|
|
16:00 - 18:30
|
Registration - Registration |
|
|
18:30 - 18:30
|
Welcome address |
|
|
18:45 - 19:25
|
A. M. Tamburro Memorial Lecture by R. Mecham - Robert Mecham, Washington University, St Louis, USA |
|
|
19:30 - 21:30
|
Opening Gala |
|
Thursday, September 4, 2014
| Time |
Event |
|
|
08:45 - 09:00
|
Opening - Registration - Welcome |
|
|
09:00 - 10:40
|
Session I : Molecular and supramolecular structure of the elastic fibers - A. Pepe & A. Weiss |
|
| 09:00 - 09:20 |
› Structure - function studies of self assembled elastomeric proteins - Régis Pomès, Structural Biology and Biochemistry, Hospital for Sick Children |
|
| 09:25 - 09:45 |
› Cutaneous fibrillin microfibrils: sacrificial proteins in UV-exposed skin? - Michael Sherratt, The University of Manchester [Manchester] |
|
| 09:50 - 10:10 |
› Geographical ancestry influences fibrillin microfibril macromolecular structure - Rachel Watson, The University of Manchester [Manchester] |
|
| 10:15 - 10:35 |
› Nanostructural studies of LTBP-1 reveal an extended but flexible structure that can be stabilized by the presence of latent TGFbeta - Clair Baldock, Faculty of Life Sciences [Manchester] |
|
|
10:40 - 11:10
|
Coffee break |
|
|
11:10 - 13:00
|
Session I : Molecular and supramolecular structure of the elastic fibers - S. Mithieux & K. Kielty |
|
| 11:10 - 11:30 |
› Towards a Detailed Molecular Picture of Elastin with Solid-State NMR - Kristin Kumashiro, University of Hawaii at Manoa, Chemistry Department |
|
| 11:35 - 11:55 |
› Modeling the Effects of Polymorphisms and Splice Variations in Human Tropoelastin on Self-Assembly and Material Properties - Fred Keeley, Research Institute, Hospital for Sick Children, Toronto, Canada |
|
| 12:00 - 12:20 |
› Approaching atomistic structural detail of elastin-like polypeptide self-assembly - Sean Reichheld, Research Institute, Hospital for Sick Children, Toronto, Canada |
|
| 12:25 - 12:45 |
› Cell interactions, order and disorder in human tropoelastin - Tony Weiss, Molecular Bioscience, University of Sydney |
|
|
13:00 - 15:00
|
Lunch |
|
|
15:00 - 16:40
|
Session II : Elastin-based biomaterials and regenerative medicine - J. Bujan & F. Keeley |
|
| 15:00 - 15:20 |
› Elastin-like Recombinamers : versatile and bioactive biomaterials - Alessandra Girotti, CIBER - BBN, University of Valladolid - |
|
| 15:25 - 15:45 |
› Design and Characterization of elastin-based triblock peptides as self-assembling nanomaterials - Antonietta Pepe, Department of Science, University of Basilicata |
|
| 15:50 - 16:10 |
› Elastin self-assembling polypeptides as building blocks for smart biomaterials - Brigida Bochicchio, Department of Science, University of Basilicata |
|
| 16:15 - 16:35 |
› Ultra-sensitive Calorimetry as a tool for Proteins and Bio macromolecules Structure and Thermodynamics - Jacques LOUBENS, TA Instruments |
|
|
16:40 - 17:10
|
Coffee break |
|
|
17:10 - 19:00
|
Session II : Elastin-based biomaterials and regenerative medicine - M. Spina & R. P. Mecham |
|
| 17:10 - 17:30 |
› Rational design of elastin-based materials: relating structure and mechanical properties - Lisa Muiznieks, Research Institute, Hospital for Sick Children, Toronto, Canada |
|
| 17:35 - 17:55 |
› Arterial extracellular matrix: a mechanobiological study of the contribution and interaction of elastin and collagen - Katherine Zhang, Department of Mechanical Engineering [Boston] |
|
| 18:00 - 18:20 |
› Dielectric spectroscopies as a tool to study the dynamics of elastin-like polypeptides |
|
|
19:00 - 20:00
|
Foundation Bemberg Visit - Visit of the wonderful Foundation Bemberg collections |
|
Friday, September 5, 2014
| Time |
Event |
|
|
08:45 - 09:00
|
Opening - Registration - Welcome |
|
|
09:00 - 10:40
|
Session III : Biochemistry of elastic fibers - M. P. Jacob & L. Muiznieks |
|
| 09:00 - 09:20 |
› Tackling elastin cross-links - Andrea Heinz, Institute of Pharmacy, Martin Luther University |
|
| 09:25 - 09:45 |
› Elastin fragmentation and its relevance to the cardiovascular continuum - Laurent Debelle, Université de Reims Champagne Ardenne |
|
| 09:50 - 10:10 |
› A novel cell adhesion region in tropoelastin that mediates attachment to integrin alphaVbeta5 - Pearl Lee, School of Molecular Biosciences, University of Sydney |
|
| 10:15 - 10:35 |
› Long-term Preclinical Evaluation of decellularized allogeneic heart valves self - regenaration potential - Michel Spina, Department of Cardiac, University of Padua |
|
|
10:40 - 11:10
|
Coffee break |
|
|
11:10 - 13:10
|
Session IV : Elastic fiber-associated cell signalling and epigenetics - D. Quaglino & R. Pomès |
|
| 11:10 - 11:30 |
› Circulating elastin peptides and the elastin receptor. Age-related modifications,pathological consequences - Ladislas ROBERT, HOPITAL HOTEL DIEU |
|
| 11:35 - 11:55 |
› NADPH oxidase 4 (NOX4) aggravates the cardiovascular phenotype in Marfan syndrome - Gustavo Egea, University of Barcelona School of Medicine |
|
| 12:00 - 12:20 |
› Interplay between elastic tissues and epigenetics: who does what? - Romain Debret, Laboratory of Tissue Biology and Therapeutic Engineering |
|
| 12:25 - 12:45 |
› A new therapeutic strategy based on matrix modulation in melanoma development - Amandine Scandolera, Laboratoire Signalisation et Récepteurs Matriciels - Unité MEDyC, UMR CNRS / URCA N° 7369 |
|
|
13:10 - 15:00
|
Lunch |
|
|
15:00 - 18:00
|
Toulouse city center tour - Toulouse city center tour |
|
|
20:00 - 22:00
|
Banquet |
|
Saturday, September 6, 2014
| Time |
Event |
|
|
08:45 - 09:00
|
Opening - Registration - Welcome |
|
|
09:00 - 11:00
|
Session V: Elastin fiber diseases and therapeutic advances - K. Kumashiro & P. Sommer |
|
| 09:00 - 09:20 |
› New molecules associated to elastic fiber calcification are revealed by mass spectrometry - Daniela Quaglino, University of Modena and Reggio Emilia |
|
| 09:25 - 09:45 |
› Efficiency of exome sequencing for the diagnosis of Pseudoxanthoma Elasticum. - Olivier Vanakker, Center for Medical Genetics, Ghent University Hospital |
|
| 09:50 - 10:10 |
› Comprehensive evaluation of the FBN1, LTBP2 and ADAMTSL4 genes in 667 patients with ectopia lentis - Bert Callewaert, Center for Medical Genetics, Ghent University Hospital |
|
| 10:15 - 10:35 |
› Perturbation of Specific Pro-mineralizing Signalling Pathways in Human and Murine Pseudoxanthoma Elasticum - Olivier Vanakker, Center for Medical Genetics, Ghent University Hospital |
|
|
10:40 - 11:10
|
Coffee break |
|
|
11:10 - 12:45
|
Session V: Elastin fiber diseases and therapeutic advances - O. Vanakker & L. Debelle |
|
| 11:10 - 11:30 |
› 3D micro computed X-ray tomography of extracellular matrix assemblies in pressurized and aged arteries - Michael Sherratt, The University of Manchester [Manchester] |
|
| 11:35 - 11:55 |
› Mechanisms of hypoxia induced dysregulation of elastic fibers synthesis - Jérémy BOIZOT, Institut de biologie et chimie des protéines [Lyon] |
|
| 12:00 - 12:20 |
› Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema - Azzaq Belaaouaj, Centre International de Recherche en Infectiologie |
|
| 12:25 - 12:45 |
› ELASTIN-DERIVED PEPTIDES ARE NEW REGULATORS OF THROMBOSIS - Pascal MAURICE, URCA, CNRS UMR7369 MEDyC |
|
|
12:45 - 13:00
|
Closed Session |
|
|
13:00 - 15:00
|
Lunch |
|
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