Planning

Wednesday, September 3, 2014

Time Event  
16:00 - 18:30 Registration - Registration  
18:30 - 18:30 Welcome address  
18:45 - 19:25 A. M. Tamburro Memorial Lecture by R. Mecham - Robert Mecham, Washington University, St Louis, USA  
19:30 - 21:30 Opening Gala  

Thursday, September 4, 2014

Time Event  
08:45 - 09:00 Opening - Registration - Welcome  
09:00 - 10:40 Session I : Molecular and supramolecular structure of the elastic fibers - A. Pepe & A. Weiss  
09:00 - 09:20 › Structure - function studies of self assembled elastomeric proteins - Régis Pomès, Structural Biology and Biochemistry, Hospital for Sick Children  
09:25 - 09:45 › Cutaneous fibrillin microfibrils: sacrificial proteins in UV-exposed skin? - Michael Sherratt, The University of Manchester [Manchester]  
09:50 - 10:10 › Geographical ancestry influences fibrillin microfibril macromolecular structure - Rachel Watson, The University of Manchester [Manchester]  
10:15 - 10:35 › Nanostructural studies of LTBP-1 reveal an extended but flexible structure that can be stabilized by the presence of latent TGFbeta - Clair Baldock, Faculty of Life Sciences [Manchester]  
10:40 - 11:10 Coffee break  
11:10 - 13:00 Session I : Molecular and supramolecular structure of the elastic fibers - S. Mithieux & K. Kielty  
11:10 - 11:30 › Towards a Detailed Molecular Picture of Elastin with Solid-State NMR - Kristin Kumashiro, University of Hawaii at Manoa, Chemistry Department  
11:35 - 11:55 › Modeling the Effects of Polymorphisms and Splice Variations in Human Tropoelastin on Self-Assembly and Material Properties - Fred Keeley, Research Institute, Hospital for Sick Children, Toronto, Canada  
12:00 - 12:20 › Approaching atomistic structural detail of elastin-like polypeptide self-assembly - Sean Reichheld, Research Institute, Hospital for Sick Children, Toronto, Canada  
12:25 - 12:45 › Cell interactions, order and disorder in human tropoelastin - Tony Weiss, Molecular Bioscience, University of Sydney  
13:00 - 15:00 Lunch  
15:00 - 16:40 Session II : Elastin-based biomaterials and regenerative medicine - J. Bujan & F. Keeley  
15:00 - 15:20 › Elastin-like Recombinamers : versatile and bioactive biomaterials - Alessandra Girotti, CIBER - BBN, University of Valladolid -  
15:25 - 15:45 › Design and Characterization of elastin-based triblock peptides as self-assembling nanomaterials - Antonietta Pepe, Department of Science, University of Basilicata  
15:50 - 16:10 › Elastin self-assembling polypeptides as building blocks for smart biomaterials - Brigida Bochicchio, Department of Science, University of Basilicata  
16:15 - 16:35 › Ultra-sensitive Calorimetry as a tool for Proteins and Bio macromolecules Structure and Thermodynamics - Jacques LOUBENS, TA Instruments  
16:40 - 17:10 Coffee break  
17:10 - 19:00 Session II : Elastin-based biomaterials and regenerative medicine - M. Spina & R. P. Mecham  
17:10 - 17:30 › Rational design of elastin-based materials: relating structure and mechanical properties - Lisa Muiznieks, Research Institute, Hospital for Sick Children, Toronto, Canada  
17:35 - 17:55 › Arterial extracellular matrix: a mechanobiological study of the contribution and interaction of elastin and collagen - Katherine Zhang, Department of Mechanical Engineering [Boston]  
18:00 - 18:20 › Dielectric spectroscopies as a tool to study the dynamics of elastin-like polypeptides  
19:00 - 20:00 Foundation Bemberg Visit - Visit of the wonderful Foundation Bemberg collections  

Friday, September 5, 2014

Time Event  
08:45 - 09:00 Opening - Registration - Welcome  
09:00 - 10:40 Session III : Biochemistry of elastic fibers - M. P. Jacob & L. Muiznieks  
09:00 - 09:20 › Tackling elastin cross-links - Andrea Heinz, Institute of Pharmacy, Martin Luther University  
09:25 - 09:45 › Elastin fragmentation and its relevance to the cardiovascular continuum - Laurent Debelle, Université de Reims Champagne Ardenne  
09:50 - 10:10 › A novel cell adhesion region in tropoelastin that mediates attachment to integrin alphaVbeta5 - Pearl Lee, School of Molecular Biosciences, University of Sydney  
10:15 - 10:35 › Long-term Preclinical Evaluation of decellularized allogeneic heart valves self - regenaration potential - Michel Spina, Department of Cardiac, University of Padua  
10:40 - 11:10 Coffee break  
11:10 - 13:10 Session IV : Elastic fiber-associated cell signalling and epigenetics - D. Quaglino & R. Pomès  
11:10 - 11:30 › Circulating elastin peptides and the elastin receptor. Age-related modifications,pathological consequences - Ladislas ROBERT, HOPITAL HOTEL DIEU  
11:35 - 11:55 › NADPH oxidase 4 (NOX4) aggravates the cardiovascular phenotype in Marfan syndrome - Gustavo Egea, University of Barcelona School of Medicine  
12:00 - 12:20 › Interplay between elastic tissues and epigenetics: who does what? - Romain Debret, Laboratory of Tissue Biology and Therapeutic Engineering  
12:25 - 12:45 › A new therapeutic strategy based on matrix modulation in melanoma development - Amandine Scandolera, Laboratoire Signalisation et Récepteurs Matriciels - Unité MEDyC, UMR CNRS / URCA N° 7369  
13:10 - 15:00 Lunch  
15:00 - 18:00 Toulouse city center tour - Toulouse city center tour
 
20:00 - 22:00 Banquet  

Saturday, September 6, 2014

Time Event  
08:45 - 09:00 Opening - Registration - Welcome  
09:00 - 11:00 Session V: Elastin fiber diseases and therapeutic advances - K. Kumashiro & P. Sommer  
09:00 - 09:20 › New molecules associated to elastic fiber calcification are revealed by mass spectrometry - Daniela Quaglino, University of Modena and Reggio Emilia  
09:25 - 09:45 › Efficiency of exome sequencing for the diagnosis of Pseudoxanthoma Elasticum. - Olivier Vanakker, Center for Medical Genetics, Ghent University Hospital  
09:50 - 10:10 › Comprehensive evaluation of the FBN1, LTBP2 and ADAMTSL4 genes in 667 patients with ectopia lentis - Bert Callewaert, Center for Medical Genetics, Ghent University Hospital  
10:15 - 10:35 › Perturbation of Specific Pro-mineralizing Signalling Pathways in Human and Murine Pseudoxanthoma Elasticum - Olivier Vanakker, Center for Medical Genetics, Ghent University Hospital  
10:40 - 11:10 Coffee break  
11:10 - 12:45 Session V: Elastin fiber diseases and therapeutic advances - O. Vanakker & L. Debelle  
11:10 - 11:30 › 3D micro computed X-ray tomography of extracellular matrix assemblies in pressurized and aged arteries - Michael Sherratt, The University of Manchester [Manchester]  
11:35 - 11:55 › Mechanisms of hypoxia induced dysregulation of elastic fibers synthesis - Jérémy BOIZOT, Institut de biologie et chimie des protéines [Lyon]  
12:00 - 12:20 › Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema - Azzaq Belaaouaj, Centre International de Recherche en Infectiologie  
12:25 - 12:45 › ELASTIN-DERIVED PEPTIDES ARE NEW REGULATORS OF THROMBOSIS - Pascal MAURICE, URCA, CNRS UMR7369 MEDyC  
12:45 - 13:00 Closed Session  
13:00 - 15:00 Lunch  
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