Session I : Molecular and supramolecular structure of the elastic fibers
A. Pepe & A. Weiss
› Structure - function studies of self assembled elastomeric proteins - Régis Pomès, Structural Biology and Biochemistry, Hospital for Sick Children
09:00-09:20 (20min)
› Cutaneous fibrillin microfibrils: sacrificial proteins in UV-exposed skin? - Michael Sherratt, The University of Manchester [Manchester]
09:25-09:45 (20min)
› Geographical ancestry influences fibrillin microfibril macromolecular structure - Rachel Watson, The University of Manchester [Manchester]
09:50-10:10 (20min)
› Nanostructural studies of LTBP-1 reveal an extended but flexible structure that can be stabilized by the presence of latent TGFbeta - Clair Baldock, Faculty of Life Sciences [Manchester]
10:15-10:35 (20min)
Session I : Molecular and supramolecular structure of the elastic fibers
S. Mithieux & K. Kielty
› Towards a Detailed Molecular Picture of Elastin with Solid-State NMR - Kristin Kumashiro, University of Hawaii at Manoa, Chemistry Department
11:10-11:30 (20min)
› Modeling the Effects of Polymorphisms and Splice Variations in Human Tropoelastin on Self-Assembly and Material Properties - Fred Keeley, Research Institute, Hospital for Sick Children, Toronto, Canada
11:35-11:55 (20min)
› Approaching atomistic structural detail of elastin-like polypeptide self-assembly - Sean Reichheld, Research Institute, Hospital for Sick Children, Toronto, Canada
12:00-12:20 (20min)
› Cell interactions, order and disorder in human tropoelastin - Tony Weiss, Molecular Bioscience, University of Sydney
12:25-12:45 (20min)
Session II : Elastin-based biomaterials and regenerative medicine
J. Bujan & F. Keeley
› Elastin-like Recombinamers : versatile and bioactive biomaterials - Alessandra Girotti, CIBER - BBN, University of Valladolid -
15:00-15:20 (20min)
› Design and Characterization of elastin-based triblock peptides as self-assembling nanomaterials - Antonietta Pepe, Department of Science, University of Basilicata
15:25-15:45 (20min)
› Elastin self-assembling polypeptides as building blocks for smart biomaterials - Brigida Bochicchio, Department of Science, University of Basilicata
15:50-16:10 (20min)
› Ultra-sensitive Calorimetry as a tool for Proteins and Bio macromolecules Structure and Thermodynamics - Jacques LOUBENS, TA Instruments
16:15-16:35 (20min)
Session II : Elastin-based biomaterials and regenerative medicine
M. Spina & R. P. Mecham
› Rational design of elastin-based materials: relating structure and mechanical properties - Lisa Muiznieks, Research Institute, Hospital for Sick Children, Toronto, Canada
17:10-17:30 (20min)
› Arterial extracellular matrix: a mechanobiological study of the contribution and interaction of elastin and collagen - Katherine Zhang, Department of Mechanical Engineering [Boston]
17:35-17:55 (20min)
› Dielectric spectroscopies as a tool to study the dynamics of elastin-like polypeptides -
18:00-18:20 (20min)
› Tackling elastin cross-links - Andrea Heinz, Institute of Pharmacy, Martin Luther University
09:00-09:20 (20min)
› Elastin fragmentation and its relevance to the cardiovascular continuum - Laurent Debelle, Université de Reims Champagne Ardenne
09:25-09:45 (20min)
› A novel cell adhesion region in tropoelastin that mediates attachment to integrin alphaVbeta5 - Pearl Lee, School of Molecular Biosciences, University of Sydney
09:50-10:10 (20min)
› Long-term Preclinical Evaluation of decellularized allogeneic heart valves self - regenaration potential - Michel Spina, Department of Cardiac, University of Padua
10:15-10:35 (20min)
Session IV : Elastic fiber-associated cell signalling and epigenetics
D. Quaglino & R. Pomès
› Circulating elastin peptides and the elastin receptor. Age-related modifications,pathological consequences - Ladislas ROBERT, HOPITAL HOTEL DIEU
11:10-11:30 (20min)
› NADPH oxidase 4 (NOX4) aggravates the cardiovascular phenotype in Marfan syndrome - Gustavo Egea, University of Barcelona School of Medicine
11:35-11:55 (20min)
› Interplay between elastic tissues and epigenetics: who does what? - Romain Debret, Laboratory of Tissue Biology and Therapeutic Engineering
12:00-12:20 (20min)
› A new therapeutic strategy based on matrix modulation in melanoma development - Amandine Scandolera, Laboratoire Signalisation et Récepteurs Matriciels - Unité MEDyC, UMR CNRS / URCA N° 7369
12:25-12:45 (20min)
Session V: Elastin fiber diseases and therapeutic advances
K. Kumashiro & P. Sommer
› New molecules associated to elastic fiber calcification are revealed by mass spectrometry - Daniela Quaglino, University of Modena and Reggio Emilia
09:00-09:20 (20min)
› Efficiency of exome sequencing for the diagnosis of Pseudoxanthoma Elasticum. - Olivier Vanakker, Center for Medical Genetics, Ghent University Hospital
09:25-09:45 (20min)
› Comprehensive evaluation of the FBN1, LTBP2 and ADAMTSL4 genes in 667 patients with ectopia lentis - Bert Callewaert, Center for Medical Genetics, Ghent University Hospital
09:50-10:10 (20min)
› Perturbation of Specific Pro-mineralizing Signalling Pathways in Human and Murine Pseudoxanthoma Elasticum - Olivier Vanakker, Center for Medical Genetics, Ghent University Hospital
10:15-10:35 (20min)
Session V: Elastin fiber diseases and therapeutic advances
O. Vanakker & L. Debelle
› 3D micro computed X-ray tomography of extracellular matrix assemblies in pressurized and aged arteries - Michael Sherratt, The University of Manchester [Manchester]
11:10-11:30 (20min)
› Mechanisms of hypoxia induced dysregulation of elastic fibers synthesis - Jérémy BOIZOT, Institut de biologie et chimie des protéines [Lyon]
11:35-11:55 (20min)
› Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema - Azzaq Belaaouaj, Centre International de Recherche en Infectiologie
12:00-12:20 (20min)
› ELASTIN-DERIVED PEPTIDES ARE NEW REGULATORS OF THROMBOSIS - Pascal MAURICE, URCA, CNRS UMR7369 MEDyC
12:25-12:45 (20min)
